Primary Identifier | MGI:2447763 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 213236 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within germ cell development. Located in cytoplasm. Is expressed in several structures, including allantois; central nervous system; gonad; head mesenchyme; and sensory organ. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1). PHENOTYPE: A semidominant mutation in the 129/Sv strain markedly increases the frequency of testicular teratomas. Homozygous males are germ cell deficient and sterile, while homozygous females have small ovaries, but usually breed. [provided by MGI curators] |