| Primary Identifier | MGI:1343091 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 15183 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin DNA binding activity; histone deacetylase activity; and histone decrotonylase activity. Involved in several processes, including cornified envelope assembly; establishment of skin barrier; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of cardiac muscle cell differentiation; regulation of DNA-templated transcription; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). PHENOTYPE: Disruption of this gene results in embryonic death at or around the time of gastrulation. Structural and functional abnormalities are also reported in mitochondria. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
