| Primary Identifier | MGI:106202 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 20730 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of protein metabolic process; regulation of calcium ion transport; and sperm capacitation. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; liver; and yolk sac. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). PHENOTYPE: Mice homozygous for a disruption in this gene results in postnatal lethality, growth retardation, dehydration, autophagic degeneration of acinar cells resulting in pancreas trophy, small intestine degeneration, and a small spleen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
