| Primary Identifier | MGI:2153182 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 140492 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables small conductance calcium-activated potassium channel activity. Involved in membrane repolarization during atrial cardiac muscle cell action potential; modulation of chemical synaptic transmission; and potassium ion transmembrane transport. Located in several cellular components, including T-tubule; Z disc; and smooth endoplasmic reticulum. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in brain; heart; and heart ventricle. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). PHENOTYPE: Mice homozygous for a point mutation exhibit tremor and gait abnormalities. Homozygous null mice lack the apamin sensitive component of the medium afterhyperpolarization current but have normal hippocampal morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
