Primary Identifier | MGI:2676830 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 387163 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within with a positive effect on hematopoietic stem cell proliferation. Acts upstream of or within several processes, including blood vessel development; cellular response to estrogen stimulus; and cellular response to ethanol. Part of RISC complex. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; lung; and oocyte. Orthologous to human MIR145 (microRNA 145). PHENOTYPE: Mice homozygous for a knock-out allele exhibit vascular smooth muscle hypotrophy, decreased blood pressure, decreased heart weight, and failure to respond normally to carotide artery ligation. [provided by MGI curators] |