| Primary Identifier | MGI:2444639 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 107035 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T cell mediated immune response to tumor cell; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of neuron projection development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; limb bud; retina; spleen; and testis. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 6. Orthologous to human FBXO38 (F-box protein 38). PHENOTYPE: Mice homozygous for a null allele exhibit incomplete prenatal lethality, defective in Sertoli cell maturation, delayed first wave of spermatogenesis, oligospermia, and reduced male fertility [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
