| Primary Identifier | MGI:2445053 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 320924 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable collagen binding activity and protease binding activity. Involved in positive regulation of angiogenesis and positive regulation of lymphangiogenesis. Acts upstream of or within several processes, including lymphangiogenesis; positive regulation of endothelial cell migration; and respiratory system process. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of collagen trimer. Is expressed in several structures, including anterior cardinal vein; branchial arch; embryo mesenchyme; heart; and intraembryonic coelom. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human CCBE1 (collagen and calcium binding EGF domains 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal lethality associated with edema and absence of lymphatic vessels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
