Primary Identifier | MGI:1346031 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 110796 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within anterior/posterior pattern specification; middle ear morphogenesis; and soft palate development. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and limb. Orthologous to human TSHZ1 (teashirt zinc finger homeobox 1). PHENOTYPE: Mice homozygous for a null allele die shortly after birth of respiratory distress, have defects in soft palate formation, have altered axial skeleton and have middle ear defects. [provided by MGI curators] |