Primary Identifier | MGI:2685179 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 240476 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryo; extraembryonic component; primitive endoderm; and yolk sac. Orthologous to human ZNF407 (zinc finger protein 407). PHENOTYPE: Mice homozygous for a knock-out allele exhibit failure of blastocyst formation and complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and show no further development after 3 days in culture. [provided by MGI curators] |