| Primary Identifier | MGI:2180216 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 246317 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ionotropic glutamate receptor binding activity. Involved in learning or memory; protein localization to synapse; and regulation of long-term neuronal synaptic plasticity. Acts upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Located in excitatory synapse and postsynaptic density. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system; metencephalon lateral wall; and retina inner nuclear layer. Orthologous to human NETO1 (neuropilin and tolloid like 1). PHENOTYPE: Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
