Primary Identifier | MGI:3039602 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 225825 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity; integrin binding activity; and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and increased incidence of tumor formation and mortality. [provided by MGI curators] |