| Primary Identifier | MGI:1930088 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 56708 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity. Involved in cell surface receptor signaling pathway via STAT; positive regulation of B cell activation; and positive regulation of astrocyte differentiation. Acts upstream of or within B cell differentiation and cell surface receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular space. Predicted to be part of CNTFR-CLCF1 complex and CRLF-CLCF1 complex. Predicted to be active in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and skeletal musculature. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 2. Orthologous to human CLCF1 (cardiotrophin like cytokine factor 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality associated with a failure to suckle and decreased facial and spinal motor neurons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
