Primary Identifier | MGI:2385612 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 225875 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Located in cell surface. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; liver; primary head vein; reproductive system; and sensory organ. Orthologous to human LRFN4 (leucine rich repeat and fibronectin type III domain containing 4). PHENOTYPE: Mice homozygous for a knock-out allele display hypoactivity and a decreased excitatory synapse number in the hippocampal CA1 region, but show normal synaptic plasticity and hippocampus-dependent learning and memory. [provided by MGI curators] |