| Primary Identifier | MGI:1336895 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 19671 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables endopeptidase activity. Involved in CAAX-box protein maturation. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit loss of proteolytic processing and methylation of farnesylated Ras proteins, reduced size, and late-gestational or early postnatal lethality. Conditional KO in the retina results in degeneration of the retinal outer nuclear layer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
