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Protein Coding Gene : Catsper1 cation channel, sperm associated 1
Primary Identifier  MGI:2179947 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  225865
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; fusion of sperm to egg plasma membrane involved in single fertilization; and regulation of cilium beat frequency involved in ciliary motility. Located in plasma membrane and sperm principal piece. Part of CatSper complex. Is expressed in germ cell of testis; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 7. Orthologous to human CATSPER1 (cation channel sperm associated 1).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit sperm with markedly decreased motility that are unable to fertilize ova and lack a calcium ion influx response to cyclic-AMP. [provided by MGI curators]
  • synonyms:
  • cation channel, sperm associated 1,
  • KSper,
  • Catsper1
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