Primary Identifier | MGI:1346330 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 23825 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. Acts upstream of or within DNA integration. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in Nestor-Guillermo progeria syndrome. Orthologous to human BANF1 (barrier to autointegration nuclear assembly factor 1). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |