| Primary Identifier | MGI:1330290 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 18426 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; negative regulation of transcription by RNA polymerase II; and regulation of meiotic cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human OVOL1 (ovo like transcriptional repressor 1). PHENOTYPE: Null mutant homozygotes show reduced growth, abnormal hair, and cystic kidneys. Females are subfertile with dilated uterus and cervix, and constricted or imperforate vagina. Mutant males have small testes, with few mature germ cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
