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Protein Coding Gene : Syvn1 synovial apoptosis inhibitor 1, synoviolin
Primary Identifier  MGI:1921376 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  74126
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables ubiquitin protein ligase activity. Involved in immature B cell differentiation; protein stabilization; and proteolysis involved in protein catabolic process. Acts upstream of or within in utero embryonic development and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum quality control compartment. Is expressed in rib. Orthologous to human SYVN1 (synoviolin 1).
PHENOTYPE: Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells. [provided by MGI curators]
  • synonyms:
  • Syvn1,
  • Hrd1,
  • RIKEN cDNA 1200010C09 gene,
  • expressed sequence AW211966,
  • MGI:2147800,
  • synovial apoptosis inhibitor 1, synoviolin,
  • AW211966,
  • expressed sequence C85322,
  • 1200010C09Rik,
  • MGI:2147717,
  • C85322
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