| Primary Identifier | MGI:99638 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 13728 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; generation of neurons; and regulation of neuron projection development. Predicted to act upstream of or within Wnt signaling pathway and cell differentiation. Located in basal cortex and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; early conceptus; and oocyte. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit proportionate dwarfism with smaller pituitaries and reduced growth hormone and prolactin secretion. Mutants develop autoimmunity and fail to breed when mated to each other. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
