Primary Identifier | MGI:2179715 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 225845 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phospholipase A1 activity and phospholipase A2 activity. Involved in several processes, including ether lipid metabolic process; lens fiber cell differentiation; and regulation of adipose tissue development. Acts upstream of or within response to bacterium. Located in several cellular components, including nuclear envelope; perinuclear region of cytoplasm; and peroxisome. Orthologous to human PLAAT3 (phospholipase A and acyltransferase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, decreased susceptibility to diet- or leptin deficiency-induced obesity, hepatic steatosis and altered glucose homeostasis. [provided by MGI curators] |