| Primary Identifier | MGI:88396 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12669 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled acetylcholine receptor activity. Involved in postsynaptic modulation of chemical synaptic transmission and regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Is active in Schaffer collateral - CA1 synapse; cholinergic synapse; and postsynaptic membrane. Is expressed in central nervous system; exocrine system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit resistance to pilocarpine-induced seizures, selective memory deficits, elevated dopaminergic transmission in the striatum, and increased spontaneous and amphetamine-induced locomotion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
