Primary Identifier | MGI:1915284 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 68034 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nuclear body. Is expressed in embryo. Orthologous to human PABIR1 (PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1). PHENOTYPE: Mice homozygous for a null allele show embryonic lethality from E9.5-E12.5 with growth defects, open anterior neural folds, somite formation and turning defects and severe cardiovascular development defects. [provided by MGI curators] |