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Polymorphic Pseudogene : Rnls renalase, FAD-dependent amine oxidase

Primary Identifier  MGI:1915045 Organism  mouse, laboratory
Chromosome  19 Mgi Type  polymorphic pseudogene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables oxidoreductase activity. Acts upstream of or within several processes, including catecholamine metabolic process; phosphate ion homeostasis; and response to norepinephrine. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline. [provided by MGI curators]
  • synonyms:
  • 6530404N21Rik,
  • RIKEN cDNA 6530404N21 gene,
  • renalase, FAD-dependent amine oxidase,
  • Rnls

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