| Primary Identifier | MGI:2147577 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 107221 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled receptor activity; fatty acid binding activity; and taste receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cell differentiation; and regulation of peptide hormone secretion. Acts upstream of or within G protein-coupled receptor signaling pathway and hormone secretion. Located in cilium; endocytic vesicle; and plasma membrane. Is expressed in brown fat; intestine; and liver. Orthologous to human FFAR4 (free fatty acid receptor 4). PHENOTYPE: Homozygotes for a null allele show altered taste responses to fatty acids. Homozygotes for another null allele develop obesity, liver steatosis, and impaired glucose metabolism, adipogenesis and lipogenesis on a high-fat diet. Homozygotes for a third allele show altered islet somatostatin secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
