Primary Identifier | MGI:97552 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 18648 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphoglycerate mutase activity. Involved in gluconeogenesis. Located in myelin sheath. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1). PHENOTYPE: Knock-out of this gene results in embryonic lethality before E13.5. T cell-specific knock-out affects glycolysis, which causes a reduced T cell inflammatory response. [provided by MGI curators] |