| Primary Identifier | MGI:99484 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12675 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables IkappaB kinase activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of interferon-alpha production; and response to virus. Acts upstream of or within several processes, including mammary gland development; osteoclast differentiation; and response to muscle stretch. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb. Used to study fetal encasement syndrome. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). PHENOTYPE: Homozygotes for targeted null mutations die neonataly and exhibit thickened, taut, adhesive skin that prevents appendages from protruding from the trunk, absence of whiskers, skeletal abnormalities, and closed esophagus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
