| Primary Identifier | MGI:1914366 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 67116 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human CUEDC2 (CUE domain containing 2). PHENOTYPE: Homozygous null mice show increased susceptibility to DSS-induced colitis and colitis-associated colon cancer, and increased macrophage proinflammatory cytokine production in response to LPS. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
