Primary Identifier | MGI:1196378 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 226243 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo endoderm; gut; liver; and yolk sac. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and thrombophilia due to thrombin defect. Orthologous to human HABP2 (hyaluronan binding protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lethality but increased liver fibrosis, inflammation and injury following bile duct ligation. [provided by MGI curators] |