| Primary Identifier | MGI:1100842 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 14585 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable glial cell-derived neurotrophic factor receptor activity; integrin binding activity; and neurotrophin receptor activity. Acts upstream of or within nervous system development. Predicted to be located in axon; extracellular space; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lung; musculoskeletal system; and nervous system. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1). PHENOTYPE: Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
