| Primary Identifier | MGI:2181202 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 170768 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Acts upstream of or within several processes, including glial cell differentiation; glycolytic process; and motor behavior. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Used to study extrinsic cardiomyopathy. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). PHENOTYPE: Homozygous null mice display embryonic lethality before E8. Inducible endothelial cell-specific homozygous knockout affects glycolysis in muscle ECs, reducing their proliferation rate and their macrophage signaling, which in turn impairs revascularization and thus muscle regeneration after ischemic injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
