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Protein Coding Gene : Mastl microtubule associated serine/threonine kinase-like
Primary Identifier  MGI:1914371 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  67121
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable protein phosphatase 2A binding activity and protein serine/threonine kinase activity. Acts upstream of or within female meiosis II and positive regulation of ubiquitin protein ligase activity. Predicted to be located in centrosome; cleavage furrow; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; otic capsule; secondary oocyte; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like).
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality and mitotic abnormalities. [provided by MGI curators]
  • synonyms:
  • THC2,
  • MGI:2147807,
  • Mastl,
  • 2700091H24Rik,
  • expressed sequence C88295,
  • C88295,
  • RIKEN cDNA 2700091H24 gene,
  • microtubule associated serine/threonine kinase-like
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

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Mouse features --> Human diseases

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