| Primary Identifier | MGI:1861755 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 56876 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium-dependent protein binding activity. Involved in cellular response to gonadotropin stimulus. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia and hypogonadotropic hypogonadism 9 with or without anosmia. Orthologous to human NSMF (NMDA receptor synaptonuclear signaling and neuronal migration factor). PHENOTYPE: Mice homozygous for a knock-out allele exhibit delayed sexual maturation in female mice and reduced male and female fertility. Another null allee shows hippocampal dysplasia with reduced synapses and simplification of dendrites, reduced LTP, and deficits in hippocampus-dependent learning. Females have fewer ovarian follicles and prolonged metestrus but shorter diestrus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
