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Protein Coding Gene : Tubb4b tubulin, beta 4B class IVB
Primary Identifier  MGI:1915472 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  227613
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable GTP binding activity and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in flagellated sperm motility. Located in myelin sheath. Is active in sperm flagellum. Is expressed in brain ependyma; epithelial layer of oviduct; germ cell of testis; nasal epithelium; and respiratory system epithelium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness. Orthologous to human TUBB4B (tubulin beta 4B class IVb).
PHENOTYPE: Mice homozygous for a null allele display partial postnatal lethality and severe truncation of cilia on multi-ciliated cells. [provided by MGI curators]
  • synonyms:
  • tubulin, beta 4B class IVB,
  • Tubb2c,
  • MGC:6713,
  • Tubb4b,
  • tubulin, beta 2C,
  • MGC:28623,
  • 4930542G03Rik,
  • RIKEN cDNA 4930542G03 gene
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