| Primary Identifier | MGI:88184 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 107771 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables molecular adaptor activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; regulation of fibroblast proliferation; and regulation of macromolecule metabolic process. Predicted to act upstream of with a positive effect on negative regulation of gene expression via chromosomal CpG island methylation. Located in spindle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial lethality, reduced body weight in male mice and abnormal male reproductive system morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
