| Primary Identifier | MGI:3036242 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 227634 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable calmodulin binding activity; microtubule minus-end binding activity; and spectrin binding activity. Predicted to be involved in several processes, including cytoplasmic microtubule organization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in cytosol; microtubule; and mitotic spindle. Predicted to colocalize with microtubule minus-end. Is expressed in 1st branchial arch; central nervous system; and lens. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 12. Orthologous to human CAMSAP1 (calmodulin regulated spectrin associated protein 1). PHENOTYPE: Mice homozygous for a null allele exhibit incomplete postnatal lethality associated with seizures, decreased brain size, and abnormal neuron polarity and migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
