| Primary Identifier | MGI:1921520 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 74270 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor binding activity; cysteine-type deubiquitinase activity; and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including antiviral innate immune response; protein deubiquitination; and regulation of signal transduction. Predicted to be located in centrosome. Is expressed in ganglia; retina; and trigeminal nerve. Orthologous to human USP20 (ubiquitin specific peptidase 20). PHENOTYPE: Mice homozygous for a null allele exhibit decreased diet-induced body weight gain, reduced lipid levels in the serum and liver, improved insulin sensitivity and increased energy expenditure. Another null allele shows increased susceptibility to lethal HSV-1 infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
