Primary Identifier | MGI:2445183 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 227721 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable sphingosine-1-phosphate phosphatase activity. Acts upstream of or within negative regulation of myotube differentiation. Located in nuclear envelope. Is expressed in several structures, including diaphragm; musculature; spleen; testis; and tongue. Orthologous to human PLPP7 (phospholipid phosphatase 7 (inactive)). PHENOTYPE: Homozygous knockout affects metabolism and nuclear envelope and sarcomere structure in muscle cells, leading to muscle weakness, stunted postnatal growth and lethality before weaning. [provided by MGI curators] |