| Primary Identifier | MGI:1928368 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 64685 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity. Involved in positive regulation of inflammatory response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). PHENOTYPE: Conditional knockout in mammary epithelium alters mammary development and increases the aggressiveness and metastatic potential of induced mammary tumors. Mice homozygous for a different null allele exhibit reduced susceptibility to LPS treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
