Primary Identifier | MGI:1914185 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 66935 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in genitourinary system; limb bud; and limb ectoderm. Orthologous to human CIR1 (corepressor interacting with RBPJ, CIR1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a hypocellular placenta, abnormal placental labyrinth vasculature morphology, and complete preweaning lethality. [provided by MGI curators] |