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Protein Coding Gene : Hoxd8 homeobox D8

Primary Identifier  MGI:96209 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  15437
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; limb bud; and nervous system. Orthologous to human HOXD8 (homeobox D8).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and healthy but show minor and low penetrance homeotic transformations in both lumbar (L1 to T13) and thoracic (T8 to T7) vertebrae. [provided by MGI curators]
  • synonyms:
  • MGI:2138833,
  • Hox-5.4,
  • homeo box-4 cluster, gene 3,
  • Hoxd8,
  • MGD-MRK-10850,
  • MGI:1913985,
  • homeobox D8,
  • RIKEN cDNA 4921540P06 gene,
  • AI047735,
  • MGD-MRK-10910,
  • 4921540P06Rik,
  • Hox-4.3,
  • expressed sequence AI047735

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

1 Genomic Clusters

32 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For