Primary Identifier | MGI:1919735 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 545428 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in brain development. Acts upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Located in centrosome and cytoplasm. Is expressed in several structures, including brain; foregut; reproductive system; respiratory system; and trigeminal nerve. Orthologous to human CCDC141 (coiled-coil domain containing 141). PHENOTYPE: Homozygous knockout impairs migration of neurons in the somatosensory cortex, resulting in increased anxiety and hyperactivity. [provided by MGI curators] |