Primary Identifier | MGI:1914208 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 66958 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable disulfide oxidoreductase activity and identical protein binding activity. Predicted to be involved in brain development. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human TMX2 (thioredoxin related transmembrane protein 2). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality before implantation with abnormal morula morphology, increased cell death, and failure of blastocyst formation. [provided by MGI curators] |