Primary Identifier | MGI:1915420 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 68170 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables intraciliary transport particle A binding activity. Acts upstream of or within acrosome reaction and spermatogenesis. Located in 9+0 non-motile cilium and cytosol. Is expressed in cerebral cortex ventricular layer and retina. Orthologous to human IFTAP (intraflagellar transport associated protein). PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal and fertile under standard laboratory conditions. Under non-standard mating conditions, males show reduced sperm competitiveness, sperm head abnormalities, and reduced sperm ability to fertilize cumulus-intact eggs in vitro. [provided by MGI curators] |