Primary Identifier | MGI:102811 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 16909 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Contributes to DNA binding activity. Involved in negative regulation of erythrocyte differentiation. Acts upstream of or within embryonic hemopoiesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study acute lymphoblastic leukemia. Orthologous to human LMO2 (LIM domain only 2). PHENOTYPE: Homozygotes for a targeted null mutation exhibit lack of yolk sac erythropoiesis and die around embryonic day 10.5. [provided by MGI curators] |