| Primary Identifier | MGI:1314635 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 19419 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Involved in positive regulation of T cell differentiation in thymus and positive regulation of natural killer cell differentiation. Acts upstream of or within several processes, including mast cell degranulation; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and vesicle transport along microtubule. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; embryo; olfactory epithelium; olfactory lobe; and telencephalon mantle layer. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). PHENOTYPE: Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
