| Primary Identifier | MGI:98737 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 21825 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables extracellular matrix binding activity. Involved in several processes, including behavioral response to pain; positive regulation of macrophage chemotaxis; and positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including cellular response to nitric oxide; circulatory system development; and monocyte aggregation. Located in extracellular matrix; extracellular space; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; pancreatic ductal carcinoma; and primary open angle glaucoma. Orthologous to human THBS1 (thrombospondin 1). PHENOTYPE: Homozygous null mice show partial prenatal lethality, lordosis, kyphosis, leukocytosis, multiorgan inflammation, lung hemorrhage, pneumonia, resistance to radiation and ischemic injury, altered blood pressure and vasoactive stress responses, eye pathology, and corneal and lacrimal gland dysfunction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
