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Protein Coding Gene : Spint1 serine protease inhibitor, Kunitz type 1
Primary Identifier  MGI:1338033 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  20732
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within chordate embryonic development; extracellular matrix organization; and placenta blood vessel development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; hemolymphoid system; and sensory organ. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).
PHENOTYPE: Homozygous null mice exhibit embryonic lethality at E10.5 or earlier, growth retardation, and widespread cell apoptosis. Placental development is impaired with abnormalities in branching morphogenesis, the formation of the labyrinth layer and placental function. [provided by MGI curators]
  • synonyms:
  • Spint1,
  • HAI-1,
  • serine protease inhibitor, Kunitz type 1
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Features --> Cross References

Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

5 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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