| Primary Identifier | MGI:2442557 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 228564 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actomyosin structure organization; negative regulation of cell motility; and positive regulation of cell adhesion. Predicted to be located in adherens junction. Predicted to be active in cytoskeleton. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD5 (FERM domain containing 5). PHENOTYPE: Null mice exhibit autism spectrum disorder-like behaviors, including learning and memory dysfunction, impaired social function and repetitive stereotyped behavior, as well as dendritic abnormalities and synaptic dysfunction. Females are infertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
