| Primary Identifier | MGI:96965 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 17289 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including neutrophil clearance; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and substrate adhesion-dependent cell spreading. Predicted to be located in cytoplasm; extracellular space; and photoreceptor outer segment. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Used to study autoimmune disease. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase). PHENOTYPE: Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
