| Primary Identifier | MGI:96543 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 16176 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity. Involved in several processes, including negative regulation of cell communication; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of macromolecule biosynthetic process. Located in extracellular space and secretory granule. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; intestine; and skin. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); cervix disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta). PHENOTYPE: Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
